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Nickel‐Catalyzed Asymmetric Reductive 1,2‐Carboamination of Unactivated Alkenes
Author(s) -
He Jun,
Xue Yuhang,
Han Bo,
Zhang Chunzhu,
Wang You,
Zhu Shaolin
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201913743
Subject(s) - enantioselective synthesis , chemistry , catalysis , alkene , aryl , electrophile , nickel , regioselectivity , combinatorial chemistry , organic chemistry , alkyl
Starting from diverse alkene‐tethered aryl iodides and O‐benzoyl‐hydroxylamines, the enantioselective reductive cross‐electrophilic 1,2‐carboamination of unactivated alkenes was achieved using a chiral pyrox/nickel complex as the catalyst. This mild, modular, and practical protocol provides rapid access to a variety of β‐chiral amines with an enantioenriched aryl‐substituted quaternary carbon center in good yields and with excellent enantioselectivities. This process reveals a complementary regioselectivity when compared to Pd and Cu catalysis.