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Two‐Dimensional Tin Selenide (SnSe) Nanosheets Capable of Mimicking Key Dehydrogenases in Cellular Metabolism
Author(s) -
Gao Meng,
Wang Zhenzhen,
Zheng Huizhen,
Wang Li,
Xu Shujuan,
Liu Xi,
Li Wei,
Pan Yanxia,
Wang Weili,
Cai Xiaoming,
Wu Ren'an,
Gao Xingfa,
Li Ruibin
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201913035
Subject(s) - chemistry , citric acid cycle , tricarboxylic acid , catalysis , enzyme , alcohol dehydrogenase , dehydrogenase , metabolism , combinatorial chemistry , nad+ kinase , tin , biochemistry , organic chemistry
Abstract While dehydrogenases play crucial roles in tricarboxylic acid (TCA) cycle of cell metabolism, which are extensively explored for biomedical and chemical engineering uses, it is a big challenge to overcome the shortcomings (low stability and high costs) of recombinant dehydrogenases. Herein, it is shown that two‐dimensional (2D) SnSe is capable of mimicking native dehydrogenases to efficiently catalyze hydrogen transfer from 1‐( R )‐2‐( R ′)‐ethanol groups. In contrary to susceptible native dehydrogenases, lactic dehydrogenase (LDH) for instance, SnSe is extremely tolerant to reaction condition changes (pH, temperature, and organic solvents) and displays extraordinary reusable capability. Structure–activity analysis indicates that the single‐atom structure, Sn vacancy, and hydrogen binding affinity of SnSe may be responsible for their catalytic activity. Overall, this is the first report of a 2D SnSe nanozyme to mimic key dehydrogenases in cell metabolism.