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Retracted: The Manganese(I)‐Catalyzed Asymmetric Transfer Hydrogenation of Ketones: Disclosing the Macrocylic Privilege
Author(s) -
Passera Alessandro,
Mezzetti Antonio
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201912605
Subject(s) - chemistry , transfer hydrogenation , manganese , catalysis , ligand (biochemistry) , medicinal chemistry , hydrogen bond , combinatorial chemistry , polymer chemistry , organic chemistry , molecule , ruthenium , receptor , biochemistry
The bis(carbonyl) manganese(I) complex [Mn(CO) 2 ( 1 )]Br ( 2 ) with a chiral (NH) 2 P 2 macrocyclic ligand ( 1 ) catalyzes the asymmetric transfer hydrogenation of polar double bonds with 2‐propanol as the hydrogen source. Ketones (43 substrates) are reduced to alcohols in high yields (up to >99 %) and with excellent enantioselectivities (90–99 % ee ). A stereochemical model based on attractive CH–π interactions is proposed.