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Programming DNA Nanoassembly for Enhanced Photodynamic Therapy
Author(s) -
Pan Min,
Jiang Qunying,
Sun Junlin,
Xu Zhen,
Zhou Yizhuo,
Zhang Li,
Liu Xiaoqing
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201912574
Subject(s) - photodynamic therapy , nanocarriers , biosafety , photosensitizer , nanotechnology , cancer therapy , cancer treatment , cancer research , cancer , computer science , medicine , chemistry , materials science , drug delivery , pathology , organic chemistry
Photodynamic therapy (PDT) has extraordinary promise for the treatment of many cancers. However, its clinical progress is impaired by the intrinsic hypoxic tumor microenvironment that limits PDT efficacy and the safety concern associated with biological specificity of photosensitizers or vehicles. Now it is demonstrated that rationally designed DNA nanosponges can load and delivery photosensitizer effectively, target tumor precisely, and relieve hypoxia‐associated resistance remarkably to enhance the efficacy of PDT. Specifically, the approach exhibits a facile assembly process, provides programmable and versatile nanocarriers, and enables robust in vitro and in vivo anti‐cancer efficacy with excellent biosafety. These findings represent a practical and safe approach by designer DNA nanoassemblies to combat cancer effectively and suggest a powerful strategy for broad biomedical application of PDT.