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Site‐Selective Late‐Stage Aromatic [ 18 F]Fluorination via Aryl Sulfonium Salts
Author(s) -
Xu Peng,
Zhao Da,
Berger Florian,
Hamad Aboubakr,
Rickmeier Jens,
Petzold Roland,
Kondratiuk Mykhailo,
Bohdan Kostiantyn,
Ritter Tobias
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201912567
Subject(s) - sulfonium , chemistry , molecule , aryl , organic molecules , combinatorial chemistry , stereochemistry , organic chemistry , salt (chemistry) , alkyl
Site‐selective functionalization of C−H bonds in small complex molecules is a long‐standing challenge in organic chemistry. Herein, we report a broadly applicable and site‐selective aromatic C−H dibenzothiophenylation reaction. The conceptual advantage of this transformation is further demonstrated through the two‐step C−H [ 18 F]fluorination of a series of marketed small‐molecule drugs.
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