A Novel Approach to Functionalization of Aryl Azides through the Generation and Reaction of Organolithium Species Bearing Masked Azides in Flow Microreactors | Zendy

Ichinari Daisuke | Zendy; Ashikari Yosuke | Zendy; Mandai Kyoko | Zendy; Aizawa Yoko | Zendy; Yoshida Junichi | Zendy; Nagaki Aiichiro | Zendy

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A Novel Approach to Functionalization of Aryl Azides through the Generation and Reaction of Organolithium Species Bearing Masked Azides in Flow Microreactors

Author(s) -

Ichinari Daisuke,

Ashikari Yosuke,

Mandai Kyoko,

Aizawa Yoko,

Yoshida Junichi,

Nagaki Aiichiro

Publication year - 2020

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201912419

Subject(s) - microreactor , aryl , organolithium compounds , chemistry , triazene , surface modification , flow chemistry , combinatorial chemistry , bearing (navigation) , organic synthesis , organic chemistry , catalysis , computer science , alkyl , ion , artificial intelligence , deprotonation

A novel straightforward method for aryl azides having functional groups based on generation and reactions of aryllithiums bearing a triazene group from polybromoarenes using flow microreactor systems was achieved. The present approach will serve as a powerful method in organolithium chemistry and open a new possibility in the synthesis of polyfunctional organic azides.

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