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A Novel Approach to Functionalization of Aryl Azides through the Generation and Reaction of Organolithium Species Bearing Masked Azides in Flow Microreactors
Author(s) -
Ichinari Daisuke,
Ashikari Yosuke,
Mandai Kyoko,
Aizawa Yoko,
Yoshida Junichi,
Nagaki Aiichiro
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201912419
Subject(s) - microreactor , aryl , organolithium compounds , chemistry , triazene , surface modification , flow chemistry , combinatorial chemistry , bearing (navigation) , organic synthesis , organic chemistry , catalysis , computer science , alkyl , ion , artificial intelligence , deprotonation
A novel straightforward method for aryl azides having functional groups based on generation and reactions of aryllithiums bearing a triazene group from polybromoarenes using flow microreactor systems was achieved. The present approach will serve as a powerful method in organolithium chemistry and open a new possibility in the synthesis of polyfunctional organic azides.