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A Light‐up Logic Platform for Selective Recognition of Parallel G‐Quadruplex Structures via Disaggregation‐Induced Emission
Author(s) -
Deiana Marco,
Chand Karam,
Jamroskovic Jan,
Obi Ikenna,
Chorell Erik,
Sabouri Nasim
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201912027
Subject(s) - supramolecular chemistry , conjugate , g quadruplex , chemistry , molecular recognition , combinatorial chemistry , nanotechnology , mechanism (biology) , molecular machine , acridine , dna , molecule , materials science , physics , biochemistry , mathematical analysis , mathematics , organic chemistry , quantum mechanics
The design of turn‐on dyes with optical signals sensitive to the formation of supramolecular structures provides fascinating and underexplored opportunities for G‐quadruplex (G4) DNA detection and characterization. Here, we show a new switching mechanism that relies on the recognition‐driven disaggregation (on‐signal) of an ultrabright coumarin‐quinazoline conjugate. The synthesized probe selectively lights‐up parallel G4 DNA structures via the disassembly of its supramolecular state, demonstrating outputs that are easily integrable into a label‐free molecular logic system. Finally, our molecule preferentially stains the G4‐rich nucleoli of cancer cells.