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Asymmetric Wacker‐Type Oxyallenylation and Azaallenylation of Cyclic Alkenes
Author(s) -
Teng Shenghan,
Jiao Zhiwei,
Chi Yonggui Robin,
Zhou Jianrong Steve
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201911961
Subject(s) - chemistry , nucleophile , catalysis , wacker process , adduct , aryl , phenols , palladium , organic chemistry , medicinal chemistry , alkyl
Palladium‐catalyzed three‐component carboetherification of cyclic alkenes proceeded to give trans adducts exclusively with excellent enantioselectivity through a Wacker‐type pathway. The reaction is also applicable to other oxygen nucleophiles, such as water, phenols, and carboxylic acids, as well as some electron‐poor aryl amines.