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Porous Cu x Co y S Supraparticles for In Vivo Telomerase Imaging and Reactive Oxygen Species Generation
Author(s) -
Li Si,
Xu Liguang,
Hao Changlong,
Sun Maozhong,
Wu Xiaoling,
Kuang Hua,
Xu Chuanlai
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201911770
Subject(s) - reactive oxygen species , fluorescence , telomerase , in vivo , oxygen , fluorescence lifetime imaging microscopy , chemistry , absorption (acoustics) , intracellular , biophysics , nanotechnology , materials science , biochemistry , biology , organic chemistry , optics , physics , microbiology and biotechnology , composite material , gene
In this study, we successfully synthesized Cu x Co y S supraparticles (SPs) on the nanoscale featuring multiple pores inside and strong absorption from 400 to 900 nm. Porous Cu x Co y S SPs produced the highest reactive oxygen species (ROS) yield (1.39) when illuminated with near‐infrared (NIR) light. Furthermore, we demonstrated that Cu x Co y S SPs could be used to identify cancer cells through intracellular telomerase‐responsive fluorescence (FL) imaging in living cells. Because the Cu x Co y S SPs were associated with telomerase‐responsive bioimaging and high ROS production, they can be efficiently used in the diagnosis and therapy of tumors with high selectivity and excellent therapeutic effects in vivo. This study provides a new vision for the creation of multifunctional SPs, which can be used as cellular sensors and control tools for pathologies across a broad range of biological systems.