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Catalytic Enantioselective Methylene C(sp 3 )−H Amidation of 8‐Alkylquinolines Using a Cp*Rh III /Chiral Carboxylic Acid System
Author(s) -
Fukagawa Seiya,
Kojima Masahiro,
Yoshino Tatsuhiko,
Matsunaga Shigeki
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201911268
Subject(s) - enantioselective synthesis , methylene , chemistry , catalysis , carboxylic acid , stereochemistry , medicinal chemistry , organic chemistry
Catalytic enantioselective directed methylene C(sp 3 )−H amidation reactions of 8‐alkylquinolines using a Cp*Rh III /chiral carboxylic acid (CCA) hybrid catalytic system are described. A binaphthyl‐based chiral carboxylic acid efficiently differentiates between the enantiotopic methylene C−H bonds, which leads to the formation of C−N bonds with good enantioselectivity.