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Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase
Author(s) -
Shi Renyi,
Wodrich Matthew D.,
Pan HuiJie,
Tirani Farzaneh Fadaei,
Hu Xile
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201910490
Subject(s) - pincer movement , pincer ligand , chemistry , cofactor , pyridinium , nickel , isomerization , hydride , nucleotide , combinatorial chemistry , stereochemistry , catalysis , biochemistry , enzyme , medicinal chemistry , organic chemistry , gene , hydrogen
A novel nickel pincer cofactor was recently discovered in lactate racemase. Reported here are three synthetic nickel pincer complexes that are both structural and functional models of the pincer cofactor in lactate racemase. DFT computations suggest the ipso ‐carbon atom of the pyridinium pincer ligands act as a hydride acceptor for lactate isomerization, whereas an organometallic pathway involving nickel‐mediated β‐hydride elimination is less favored.