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Atroposelective Arene Formation by Carbene‐Catalyzed Formal [4+2] Cycloaddition
Author(s) -
Xu Ke,
Li Wenchang,
Zhu Shaoheng,
Zhu Tingshun
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201910049
Subject(s) - carbene , cycloaddition , chemistry , organocatalysis , catalysis , formal synthesis , conjugated system , molecule , combinatorial chemistry , aryl , enantioselective synthesis , organic chemistry , polymer , alkyl
Atroposelective arene formation is an efficient method to build axially chiral molecules with multi‐substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N‐heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and α‐aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.