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Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation
Author(s) -
Li Qiyao,
Li Ying,
Min Tianliang,
Gong Junyi,
Du Lili,
Phillips David Lee,
Liu Junkai,
Lam Jacky W. Y.,
Sung Herman H. Y.,
Williams Ian D.,
Kwok Ryan T. K.,
Ho Chun Loong,
Li Kai,
Wang Jianguo,
Tang Ben Zhong
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201909706
Subject(s) - photosensitizer , photodynamic therapy , in vivo , biocompatibility , chemistry , escherichia coli , cancer cell , reactive oxygen species , fluorescence , in vitro , biophysics , ablation , photochemistry , combinatorial chemistry , cancer , biochemistry , biology , organic chemistry , medicine , genetics , physics , microbiology and biotechnology , quantum mechanics , gene
Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small Δ E ST , 4TPA‐BQ shows a satisfactorily high 1 O 2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications.