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Direct Arylation of α‐Amino C(sp 3 )‐H Bonds by Convergent Paired Electrolysis
Author(s) -
Ma Yueyue,
Yao Xiantong,
Zhang Lei,
Ni Pufan,
Cheng Ruihua,
Ye Jinxing
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201909642
Subject(s) - benzonitrile , electrolysis , chemistry , anode , stoichiometry , cathodic protection , combinatorial chemistry , metal , coupling reaction , catalysis , organic chemistry , electrode , electrolyte
A metal‐free convergent paired electrolysis strategy to synthesize benzylic amines through direct arylation of tertiary amines and benzonitrile derivatives at room temperature has been developed. This TEMPO‐mediated electrocatalytic reaction makes full use of both anodic oxidation and cathodic reduction without metals or stoichiometric oxidants, thus showing great potential and advantages for practical synthesis. This convergent paired electrolysis method provides a straightforward and powerful means to activate C−H bonds and realize cross‐coupling with cathodically generated species.