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A Nanobody‐Conjugated DNA Nanoplatform for Targeted Platinum‐Drug Delivery
Author(s) -
Wu Tiantian,
Liu Jianbing,
Liu Manman,
Liu Shaoli,
Zhao Shuai,
Tian Run,
Wei Dengshuai,
Liu Yangzhong,
Zhao Yao,
Xiao Haihua,
Ding Baoquan
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201909345
Subject(s) - nanocarriers , dna , drug delivery , chemistry , epidermal growth factor receptor , rational design , cancer research , combinatorial chemistry , nanotechnology , materials science , receptor , medicine , biochemistry , organic chemistry
The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum‐based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double‐bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA‐based platinum‐drug delivery system provides a promising strategy for the treatment of tumors.