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Surface Plasmon Resonance Microscopy: From Single‐Molecule Sensing to Single‐Cell Imaging
Author(s) -
Zhou XiaoLi,
Yang Yunze,
Wang Shaopeng,
Liu XianWei
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201908806
Subject(s) - surface plasmon resonance , nanotechnology , microscopy , instrumentation (computer programming) , surface plasmon , plasmon , materials science , optics , optoelectronics , physics , computer science , nanoparticle , operating system
Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single‐molecule sensing to single‐cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.