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Entropically Favoured Assembly of Pyrazine‐Based Helical Fibers into Superstructures: Achiral/ Chiral Guest‐Induced Chirality Transformation
Author(s) -
Sharma Sonia,
Kataria Meenal,
Kumar Manoj,
Bhalla Vandana
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201908669
Subject(s) - chirality (physics) , supramolecular chemistry , intermolecular force , stacking , supramolecular chirality , circular dichroism , chemistry , hydrogen bond , pyrazine , crystallography , materials science , nanotechnology , stereochemistry , molecule , organic chemistry , crystal structure , physics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
The development of synthetic helical structures undergoing stimuli‐responsive chirality transformations is important for an understanding of the role of chirality in natural systems. However, controlling supramolecular chirality in entropically driven assemblies in aqueous media is challenging. To develop stimuli‐responsive assemblies, we designed and synthesized pyrazine derivatives with l ‐alanine groups as chiral building blocks. These systems undergo self‐assembly in aqueous media to generate helical fibers and the embedded alanine groups transfer their chirality to the assembled structures. Furthermore, these helical fibers undergo a Ni 2+ ‐induced chirality transformation. The study demonstrates the role of intermolecular hydrogen bonding, π–π stacking, and the hydrophobic effect in the Ni 2+ ‐mediated transition of helical fibers to supercoiled helical ensembles which mimic the formation of superstructures in biopolymers.