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Asymmetric Magnesium‐Catalyzed Hydroboration by Metal‐Ligand Cooperative Catalysis
Author(s) -
Falconnet Alban,
Magre Marc,
Maity Bholanath,
Cavallo Luigi,
Rueping Magnus
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201908012
Subject(s) - hydroboration , enantioselective synthesis , chemistry , catalysis , ligand (biochemistry) , combinatorial chemistry , context (archaeology) , metal , organic chemistry , paleontology , biochemistry , receptor , biology
Asymmetric catalysis with readily available, cheap, and non‐toxic alkaline earth metal catalysts represents a sustainable alternative to conventional synthesis methodologies. In this context, we describe the development of a first Mg II ‐catalyzed enantioselective hydroboration providing the products with excellent yields and enantioselectivities. NMR spectroscopy studies and DFT calculations provide insights into the reaction mechanism and the origin of the enantioselectivity which can be explained by a metal‐ligand cooperative catalysis pathway involving a non‐innocent ligand.