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Synthesis of Indolines and Derivatives by Aza‐Heck Cyclization
Author(s) -
Xu Feiyang,
Korch Katerina M.,
Watson Donald A.
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201907758
Subject(s) - indoline , electrophile , chemistry , ring (chemistry) , heck reaction , combinatorial chemistry , organic chemistry , catalysis , palladium
For the first time, an aza‐Heck cyclization that allows the preparation of indoline scaffolds is described. Using N ‐hydroxy anilines as electrophiles, which can be easily accessed from the corresponding nitroarenes, this method provides indolines bearing pendant functionality and complex ring topologies. Synthesis of challenging indolines, such as those bearing fully substituted carbon atoms at C2, is also possible using this method.