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Rh I ‐Catalyzed P III ‐Directed C−H Bond Alkylation: Design of Multifunctional Phosphines for Carboxylation of Aryl Bromides with Carbon Dioxide
Author(s) -
Zhang Zhuan,
Roisnel Thierry,
Dixneuf Pierre H.,
Soulé JeanFrançois
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201906913
Subject(s) - carboxylation , chemistry , rhodium , alkylation , catalysis , aryl , medicinal chemistry , carbon dioxide , combinatorial chemistry , organic chemistry , alkyl
We report the C−H alkylation of biarylphosphines at the ortho′ position(s) with alkenes by using rhodium(I) catalysis, which provides straightforward access to a large library of multifunctionalized phosphines. Some of these modified ligands outperformed commercially available phosphines in the Pd‐catalyzed carboxylation of aryl bromides with carbon dioxide in the presence of a photoredox catalyst.