Premium
Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through Co III ‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls
Author(s) -
Dongbang Sun,
Shen Zican,
Ellman Jonathan A.
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201906633
Subject(s) - stereocenter , chemistry , catalysis , isoprene , component (thermodynamics) , bond cleavage , stereochemistry , combinatorial chemistry , medicinal chemistry , enantioselective synthesis , organic chemistry , copolymer , polymer , physics , thermodynamics
Abstract An efficient Co III ‐catalyzed three‐component strategy to prepare homoallylic alcohols containing acyclic quaternary centers is disclosed. This transformation enables the introduction of two C−C σ bonds through C−H bond activation and sequential addition to internally substituted dienes and a wide range of aldehydes and activated ketones. Isoprene and other internally monosubstituted dienes are effective inputs, with the reaction proceeding with high diastereoselectivity for those substrate combinations that result in more than one stereogenic center. Moreover, the opposite relative stereochemistry can be achieved by employing 1,2‐disubstituted dienes. A mechanism for the transformation is proposed based upon the relative stereochemistry of the products and studies with isotopically labeled starting materials.