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Self‐Assembly of Wireframe DNA Nanostructures from Junction Motifs
Author(s) -
Huang Kai,
Yang Donglei,
Tan Zhenyu,
Chen Silian,
Xiang Ye,
Mi Yongli,
Mao Chengde,
Wei Bryan
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201906408
Subject(s) - dna origami , planar , nanostructure , vertex (graph theory) , construct (python library) , nanotechnology , self assembly , dna nanotechnology , template , scaffold , dna , scheme (mathematics) , topology (electrical circuits) , materials science , computer science , chemistry , mathematics , theoretical computer science , combinatorics , graph , computer graphics (images) , biochemistry , mathematical analysis , programming language , database
Wireframe frameworks have been investigated for the construction of complex nanostructures from a scaffolded DNA origami approach; however, a similar framework is yet to be fully explored in a scaffold‐free “LEGO” approach. Herein, we describe a general design scheme to construct wireframe DNA nanostructures entirely from short synthetic strands. A typical edge of the resulting structures in this study is composed of two parallel duplexes with crossovers on both ends, and three, four, or five edges radiate out from a certain vertex. By using such a self‐assembly scheme, we produced planar lattices and polyhedral objects.