Self‐Assembly of Wireframe DNA Nanostructures from Junction Motifs | Zendy

Huang Kai | Zendy; Yang Donglei | Zendy; Tan Zhenyu | Zendy; Chen Silian | Zendy; Xiang Ye | Zendy; Mi Yongli | Zendy; Mao Chengde | Zendy; Wei Bryan | Zendy

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Self‐Assembly of Wireframe DNA Nanostructures from Junction Motifs

Author(s) -

Huang Kai,

Yang Donglei,

Tan Zhenyu,

Chen Silian,

Xiang Ye,

Mi Yongli,

Mao Chengde,

Wei Bryan

Publication year - 2019

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201906408

Subject(s) - dna origami , planar , nanostructure , vertex (graph theory) , construct (python library) , nanotechnology , self assembly , dna nanotechnology , template , scaffold , dna , scheme (mathematics) , topology (electrical circuits) , materials science , computer science , chemistry , mathematics , theoretical computer science , combinatorics , graph , computer graphics (images) , biochemistry , mathematical analysis , programming language , database

Wireframe frameworks have been investigated for the construction of complex nanostructures from a scaffolded DNA origami approach; however, a similar framework is yet to be fully explored in a scaffold‐free “LEGO” approach. Herein, we describe a general design scheme to construct wireframe DNA nanostructures entirely from short synthetic strands. A typical edge of the resulting structures in this study is composed of two parallel duplexes with crossovers on both ends, and three, four, or five edges radiate out from a certain vertex. By using such a self‐assembly scheme, we produced planar lattices and polyhedral objects.

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