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Pyridine/Oxadiazole‐Based Helical Foldamer Ion Channels with Exceptionally High K + /Na + Selectivity
Author(s) -
Chen Feng,
Shen Jie,
Li Ning,
Roy Arundhati,
Ye Ruijuan,
Ren Changliang,
Zeng Huaqiang
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201906341
Subject(s) - selectivity , foldamer , chemistry , heteroatom , ion , pyridine , crystallography , ion channel , stereochemistry , medicinal chemistry , organic chemistry , alkyl , receptor , biochemistry , catalysis
Abstract Protein channels are characterized by high transport selectivity, which is essential for maintaining cellular function. Efforts to reproduce such high selectivity over the past four decades have not been very successful. We report a novel series of aromatic foldamer‐based polymeric channels where the backbone is stabilized by differential electrostatic repulsions among heteroatoms helically arrayed along the helical backbone. Nanotubes averaging 2.3 and 2.7 nm in length mediate highly efficient transport of K + ions as a consequence of hydrophilic electron‐rich hollow cavities that are 3 Å in diameter. Exceptionally high K + and Na + selectivity values of 16.3 and 12.6, respectively, are achieved.