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Volatile Organic Compound Based Probe for Induced Volatolomics of Cancers
Author(s) -
Lange Justin,
Eddhif Balkis,
Tarighi Mehrad,
Garandeau Théa,
Péraudeau Elodie,
Clarhaut Jonathan,
Renoux Brigitte,
Papot Sébastien,
Poinot Pauline
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201906261
Subject(s) - context (archaeology) , tumour tissue , cancer , exhaled air , chemistry , volatile organic compound , cancer research , nanotechnology , computational biology , medicine , pathology , materials science , biology , organic chemistry , toxicology , paleontology
The development of efficient protocols for cancer diagnosis remains highly challenging. An emerging approach relies on the detection in exhaled breath of volatile organic compounds (VOC) produced by tumours. In this context, described here is a novel strategy in which a VOC‐based probe is converted selectively in malignant tissues, by a tumour‐associated enzyme, for releasing the corresponding VOC. The latter is then detected in the exhaled breath as a tumour marker for cancer diagnosis. This approach allows the detection of several different tumours in mice, the monitoring of tumour growth and tumour response to chemotherapy. Thus, the concept of “induced volatolomics” provides a new way to explore biological processes using VOC‐based probes that could be adapted to many biomedical applications.