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Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
Author(s) -
Guo Yafei,
Harutyunyan Syuzanna R.
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201906237
Subject(s) - enantioselective synthesis , catalysis , chemistry , combinatorial chemistry , reagent , organic chemistry
General methods to prepare chiral N‐heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2‐ and 4‐substituted tetrahydro‐quinolones, dihydro‐4‐pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.