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Photochemical C−H Amination of Ethers and Geminal Difunctionalization Reactions in One Pot
Author(s) -
HernándezGuerra Daniel,
Hlavačková Anna,
Pramthaisong Chiranan,
Vespoli Ilaria,
Pohl Radek,
Slanina Tomáš,
Jahn Ullrich
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201905209
Subject(s) - geminal , chemistry , amination , reagent , sulfonyl , azide , organic chemistry , combinatorial chemistry , catalysis , alkyl
A mild, atom‐economic, and metal‐free α‐C−H amination of ethers using relatively stable nonafluorobutanesulfonyl (nonaflyl, Nf) azide as the aminating reagent to give N‐sulfonyl hemiaminals is reported. This enables unprecedented C(sp 3 ) difunctionalization reactions, leading to diverse functionalized amino group containing compounds starting from simple ethers in one pot.