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Enantioselective Palladium‐Catalyzed Cross‐Coupling of α‐Bromo Carboxamides and Aryl Boronic Acids
Author(s) -
Li Bowen,
Li Tiejun,
Aliyu Muinat A.,
Li Zhen Hua,
Tang Wenjun
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201905174
Subject(s) - transmetalation , palladium , enantioselective synthesis , aryl , chemistry , catalysis , combinatorial chemistry , ligand (biochemistry) , boronic acid , organic chemistry , biochemistry , alkyl , receptor
We herein report an enantioselective palladium‐catalyzed cross‐coupling between α‐bromo carboxamides and aryl boronic acids, generating a series of chiral α‐aryl carboxamides in good yields and excellent enantioselectivities. The development of a chiral P,P=O ligand was critical in overcoming the second transmetalation issue and allows the first asymmetric palladium‐catalyzed coupling of α‐bromo carbonyl compounds.