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Rhodium‐Catalyzed Asymmetric Intramolecular Hydroamination of Allenes
Author(s) -
Berthold Dino,
Geissler Arne G. A.,
Giofré Sabrina,
Breit Bernhard
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201904833
Subject(s) - hydroamination , rhodium , intramolecular force , catalysis , chemistry , stereochemistry , organic chemistry
The rhodium‐catalyzed asymmetric intramolecular hydroamination of sulfonyl amides with terminal allenes is reported. It provides selective access to 5‐ and 6‐membered N ‐heterocycles, scaffolds found in a large range of different bioactive compounds. Moreover, gram scale reactions, as well as the application of suitable product transformations to natural products and key intermediates thereof are demonstrated.