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A Safe and Efficient Strategy for the Rapid Elimination of Blood Lead In Vivo Based on a Capture–Fix–Separate Mechanism
Author(s) -
Wan Mi Mi,
Xu Ting Ting,
Chi Bo,
Wang Meng,
Huang Yangyang,
Wang Qi,
Li Ting,
Yan Wen Qiang,
Chen Huan,
Xu Ping,
Mao Chun,
Zhao Bo,
Shen Jian,
Xu Hong,
Shi Dong Quan
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201904044
Subject(s) - lead (geology) , in vivo , hemoglobin , chemistry , biocompatibility , mesoporous material , nanotechnology , materials science , catalysis , biochemistry , organic chemistry , biology , paleontology , microbiology and biotechnology
Lead poisoning is an important problem because of its serious effects on human health. Yet a solution is not available due to an incomplete understanding of the state of lead ions in blood. Since most blood lead binds to hemoglobin (Hb) in red blood cells, identifying and capturing lead‐contaminated Hb in RBCs is important. Herein, a magnetic blood lead remover with hyperbranched poly(amidoamine)s (HPAM) as template/co‐adsorbent and core–shell mesoporous structure was synthesized. Lead‐containing Hb was selectively captured and then fixed by mesoporous channels. The magnetic separation technology was used to separate the magnetic remover from blood. A related blood lead clean‐up apparatus was used to remove lead from the blood of a pig in vivo. Results of physical/chemical characterizations, biocompatibility experiments, animal tests, and theoretical simulation verify the safety and efficiency of this removal strategy and the high efficiency of the blood lead clean‐up apparatus.