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Synthetic Haptens and Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
Author(s) -
QuiñonesReyes Guillermo,
Agulló Consuelo,
Mercader Josep V.,
AbadSomovilla Antonio,
AbadFuentes Antonio
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201904002
Subject(s) - cyanotoxin , hapten , monoclonal antibody , chemistry , antibody , environmental chemistry , cyanobacteria , microcystin , biology , immunology , genetics , bacteria
Early warning systems for monitoring toxic events may benefit from the availability of monoclonal antibodies enabling the sensitive and specific detection of anatoxin‐a, a cyanotoxin involved in numerous cases of animal poisoning resulting from toxic algal blooms in freshwaters. Through the synthesis of three functionalized derivatives of anatoxin‐a, we have succeeded in generating the first‐ever reported immunoreagents (bioconjugates and antibodies) suitable for the development of immunoanalytical approaches aimed at rapid and onsite detection of this harmful cyanotoxin.