Carbonylation of C−N Bonds in Tertiary Amines Catalyzed by Low‐Valent Iron Catalysts | Zendy

Nasr Allah Tawfiq | Zendy; Savourey Solène | Zendy; Berthet JeanClaude | Zendy; Nicolas Emmanuel | Zendy; Cantat Thibault | Zendy

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Carbonylation of C−N Bonds in Tertiary Amines Catalyzed by Low‐Valent Iron Catalysts

Author(s) -

Nasr Allah Tawfiq,

Savourey Solène,

Berthet JeanClaude,

Nicolas Emmanuel,

Cantat Thibault

Publication year - 2019

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201903740

Subject(s) - catalysis , carbonylation , chemistry , lewis acids and bases , medicinal chemistry , organic chemistry , polymer chemistry , carbon monoxide

The first iron catalysts able to promote the formal insertion of CO into the C−N bond of amines are reported. Using low‐valent iron complexes, including K 2 [Fe(CO) 4 ], amides are formed from aromatic and aliphatic amines, in the presence of an iodoalkane promoter. Inorganic Lewis acids, such as AlCl 3 and Nd(OTf) 3 , have a positive influence on the catalytic activity of the iron salts, enabling the carbonylation at a low pressure of CO (6 to 8 bars).

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