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Selective Aerobic Oxygenation of Tertiary Allylic Alcohols with Molecular Oxygen
Author(s) -
Zhu Bencong,
Shen Tao,
Huang Xiaoqiang,
Zhu Yuchao,
Song Song,
Jiao Ning
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201903690
Subject(s) - allylic rearrangement , chemistry , molecular oxygen , solvent , oxygen , oxygenation , catalysis , copper , organic chemistry , combinatorial chemistry , ecology , biology
Aerobic epoxidation of tertiary allylic alcohols remains a significant challenge. Reported here is an efficient and highly chemoselective copper‐catalyzed epoxidation and semipinacol rearrangement reaction of tertiary allylic alcohols with molecular oxygen. The solvent 1,4‐dioxane activates dioxygen, thereby precluding the addition of a sacrificial reductant.