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Tm 3+ ‐Sensitized NIR‐II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding
Author(s) -
Zhang Hongxin,
Fan Yong,
Pei Peng,
Sun Caixia,
Lu Lingfei,
Zhang Fan
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201903536
Subject(s) - fluorescence , decoding methods , near infrared spectroscopy , multiplexing , in vivo , nanocrystal , fluorescence lifetime imaging microscopy , optical storage , materials science , excitation , chemistry , optoelectronics , nanotechnology , optics , physics , computer science , telecommunications , microbiology and biotechnology , biology , quantum mechanics
In vivo fluorescence imaging in the second near‐infrared window (NIR‐II) affords deep‐tissue penetration and high spatial resolution. Herein, we present a new type of Tm 3+ ‐sensitized lanthanide nanocrystals with both excitation (1208 nm) and emission (1525 nm) located in the NIR‐II window for in vivo optical information storage and decoding. Taking advantage of the tunable fluorescence lifetimes, the optical multiplexed encoding capacity is enhanced accordingly. Micro‐devices with QR codes featuring the NIR‐II fluorescence‐lifetime multiplexed encoding were implanted into mice and were successfully decoded through time‐gated fluorescence imaging technology.