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Metal–Organic Framework (MOF) Hybrid as a Tandem Catalyst for Enhanced Therapy against Hypoxic Tumor Cells
Author(s) -
Liu Jintong,
Liu Tianrui,
Du Ping,
Zhang Lei,
Lei Jianping
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201903475
Subject(s) - singlet oxygen , photothermal therapy , photodynamic therapy , catalase , chemistry , catalysis , metal organic framework , quantum yield , nanoparticle , nanotechnology , materials science , oxygen , organic chemistry , biochemistry , oxidative stress , physics , adsorption , quantum mechanics , fluorescence
Encapsulation of active biomolecules and/or nanoparticles in metal–organic frameworks (MOFs) remains a great challenge in biomedical applications. In this work, through a stepwise in situ growth method, a black phosphorus quantum dot (BQ) and catalase were precisely encapsulated into the inner and outer layers of MOFs, respectively. The integrated MOF system as a tandem catalyst could convert H 2 O 2 into O 2 in MOF‐stabilized catalase outer layer, and then O 2 was directly injected into MOF‐sensitized BQ inner, leading to high quantum yield of singlet oxygen. Upon internalization, the photodynamic therapy efficiency of the MOF system was 8.7‐fold greater than that without catalase, showing an enhanced therapeutic effect against hypoxic tumor cells. Furthermore, by coupling with photothermal therapy of BQs, photodynamic‐thermal synergistic therapy was realized both in vitro and in vivo.