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CeVO 4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species
Author(s) -
Singh Namrata,
Mugesh Govindasamy
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201903427
Subject(s) - chemistry , superoxide , oxygen , cytochrome c , radical , photochemistry , electron transport chain , catalysis , cytochrome c oxidase , oxidase test , peroxide , redox , oxygen reduction , cytochrome , inorganic chemistry , enzyme , electrochemistry , organic chemistry , biochemistry , mitochondrion , electrode
In this study, we report a remarkably active CeVO 4 nanozyme that functionally mimics cytochrome c oxidase (C c O), the terminal enzyme in the respiratory electron transport chain, by catalyzing a four‐electron reduction of dioxygen to water. The nanozyme catalyzes the reaction by using cytochrome c (Cyt c ), the biological electron donor for C c O, at physiologically relevant pH. The C c O activity of the CeVO 4 nanozymes depends on the relative ratio of surface Ce 3+ /Ce 4+ ions, the presence of V 5+ and the surface‐Cyt c interactions. The complete reduction of oxygen to water takes place without release of any partially reduced oxygen species (PROS) such as superoxide, peroxide and hydroxyl radicals.