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Direct Monitoring of Cell Membrane Vesiculation with 2D AuNP@MnO 2 Nanosheet Supraparticles at the Single‐Particle Level
Author(s) -
Ling Yunyun,
Zhang Di,
Cui Ximin,
Wei Meimei,
Zhang Ting,
Wang Jianfang,
Xiao Lehui,
Xia Yunsheng
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201902987
Subject(s) - colloidal gold , nanotechnology , nanosheet , surface plasmon resonance , materials science , membrane , nanoparticle , endocytosis , nanomaterials , particle (ecology) , plasmon , chemistry , cell , optoelectronics , biochemistry , oceanography , geology
We herein demonstrate robust two‐dimensional (2D) UFO‐shaped plasmonic supraparticles made of gold nanoparticles (AuNPs) and MnO 2 nanosheets (denoted as AMNS‐SPs) for directly monitoring cell membrane vesiculation at the single‐particle level. Because the decorated MnO 2 nanosheets are ultrathin (4.2 nm) and have large diameters (230 nm), they are flexible enough for deformation and folding for parceling of the AuNPs during the endocytosis process. Correspondingly, the surrounding refractive index of the AuNPs increases dramatically, which results in a distinct red‐shift of the localized surface plasmon resonance (LSPR). Such LSPR modulation provides a convenient and accurate means for directly monitoring the dynamic interactions between 2D nanomaterials and cell membranes. Furthermore, for the endocytosed AMNS‐SPs, the subsequent LSPR blue‐shift induced by etching effects of reducing molecules is promising for exploring the local environment redox states at the single‐cell level.