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Aqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells
Author(s) -
CarrilloCarrión Carolina,
Martínez Raquel,
Navarro Poupard María F.,
Pelaz Beatriz,
Polo Ester,
ArenasVivo Ana,
Olgiati Alessandro,
Taboada Pablo,
Soliman Mahmoud G.,
Catalán Úrsula,
FernándezCastillejo Sara,
Solà Rosa,
Parak Wolfgang J.,
Horcajada Patricia,
AlvarezPuebla Ramon A.,
del Pino Pablo
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201902817
Subject(s) - nanotechnology , raman spectroscopy , materials science , plasmon , nanocomposite , chemical engineering , polymer , aqueous solution , molecule , chemistry , organic chemistry , composite material , physics , optoelectronics , engineering , optics
A plasmonic core–shell gold nanostar/zeolitic‐imidazolate‐framework‐8 (ZIF‐8) nanocomposite was developed for the thermoplasmonic‐driven release of encapsulated active molecules inside living cells. The nanocomposites were loaded, as a proof of concept, with bisbenzimide molecules as functional cargo and wrapped with an amphiphilic polymer that prevents ZIF‐8 degradation and bisbenzimide leaking in aqueous media or inside living cells. The demonstrated molecule‐release mechanism relies on the use of near‐IR light coupled to the plasmonic absorption of the core gold nanostars, which creates local temperature gradients and thus, bisbenzimide thermodiffusion. Confocal microscopy and surface‐enhanced Raman spectroscopy (SERS) were used to demonstrate bisbenzimide loading/leaking and near‐IR‐triggered cargo release inside cells, thereby leading to DNA staining.