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Efficient Synthesis of α‐Trifluoromethyl Carboxylic Acids and Esters through Fluorocarboxylation of gem ‐Difluoroalkenes
Author(s) -
Yoo WooJin,
Kondo Junpei,
RodríguezSantamaría José A.,
Nguyen Thanh V. Q.,
Kobayashi Shū
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201902779
Subject(s) - trifluoromethyl , chemistry , fluoride , organic chemistry , combinatorial chemistry , nonsteroidal , inorganic chemistry , pharmacology , alkyl , medicine
Abstract A facile synthetic procedure for the preparation of α‐trifluoromethyl carboxylic acids and esters was achieved through multicomponent coupling reactions between gem ‐difluoroalkenes, cesium fluoride, and carbon dioxide. The products were generated in moderate to excellent yields, and the synthetic utility of this method was demonstrated through the preparation of trifluoromethylated versions of popular nonsteroidal anti‐inflammatory drugs (NSAIDs).