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Synthesis of Tri‐ and Difluoromethoxylated Compounds by Visible‐Light Photoredox Catalysis
Author(s) -
Lee Johnny W.,
Lee Katarzy.,
Ngai MingYu
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201902243
Subject(s) - photoredox catalysis , chemistry , catalysis , photocatalysis , molecule , combinatorial chemistry , visible spectrum , drug discovery , photochemistry , organic chemistry , materials science , biochemistry , optoelectronics
Trifluoromethoxy (OCF 3 ) and difluoromethoxy (OCF 2 H) groups are fluorinated structural motifs that exhibit unique physicochemical characteristics. Incorporation of these substituents into organic molecules is a highly desirable approach used in medicinal chemistry and drug discovery processes to alter the properties of a parent compound. Recently, tri‐ and difluoromethyl ethers have received increasing attention and several innovative strategies to access these valuable functional groups have been developed. The focus of this Minireview is the use of visible‐light photoredox catalysis in the synthesis of tri‐ and difluoromethyl ethers. Recent photocatalytic strategies for the formation of O−CF 3 , C−OCF 3, O−CF 2 H, and C−OCF 2 H bonds as well as other transformations leading to the construction of OR F groups are discussed herein.