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Enantioselective Arylation of Benzylic C−H Bonds by Copper‐Catalyzed Radical Relay
Author(s) -
Zhang Wen,
Wu Lianqian,
Chen Pinhong,
Liu Guosheng
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201902191
Subject(s) - enantioselective synthesis , chemistry , moiety , reactivity (psychology) , catalysis , reagent , ligand (biochemistry) , combinatorial chemistry , copper , functional group , medicinal chemistry , organic chemistry , receptor , medicine , biochemistry , polymer , alternative medicine , pathology
A novel enantioselective copper‐catalyzed arylation of benzylic C−H bonds, using alkylarenes as a limiting reagent, has been developed. A chiral bisoxazoline ligand bearing an acetate ester moiety plays a key role in both the reactivity and enantioselectivity of the reaction. The reaction provides efficient access to various chiral 1,1‐diarylalkanes in good yields with good to excellent enantioselectivities, and displays excellent functional‐group tolerance.