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A Reusable MOF‐Supported Single‐Site Zinc(II) Catalyst for Efficient Intramolecular Hydroamination of o ‐Alkynylanilines
Author(s) -
Li Beibei,
Ju Zhanfeng,
Zhou Mi,
Su Kongzhao,
Yuan Daqiang
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201902171
Subject(s) - hydroamination , intramolecular force , catalysis , metal organic framework , chemistry , zinc , combinatorial chemistry , homogeneous catalysis , heterogeneous catalysis , organic chemistry , adsorption
The exploitation of new and active earth‐abundant metal catalysts is critical for sustainable chemical production. Herein, we demonstrate the design of highly efficient, robust, and reusable Zn II ‐bipyridine‐based metal–organic framework (MOF) catalysts for the intramolecular hydroamination of o ‐alkynylanilines to indoles. Under similar conditions homogeneous catalytic systems mainly provide hydrolysate. Our results prove that MOFs support unique internal environments that can affect the direction of chemical reactions. The Zn II ‐catalyzed hydroamination reaction can be conducted without additional ligands, base, or acid, and is thus a very clean reaction system with regard to its environmental impact.