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Spontaneous Resolution by Crystallization of an Octanuclear Iron(III) Complex Using Only Racemic Reagents
Author(s) -
Lazarou Konstantinos A.,
GonzálezNieves Karilys,
Chakraborty Indranil,
Raptis Raphael G.
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201901877
Subject(s) - crystallization , enantiomer , chemistry , reagent , resolution (logic) , crystallography , circular dichroism , stereochemistry , organic chemistry , artificial intelligence , computer science
The P and M enantiomers of the octanuclear [Fe 8 (μ 4 ‐O) 4 (μ‐4‐Cl‐pz) 12 Cl 4 ] complex, having T symmetry, were resolved by temporary substitution of chloride ligands by racemic 4‐ s Bu‐phenolates and subsequent crystallization, where the ( S )‐ and ( R )‐phenolates coordinate selectively to the M and P complexes, respectively. The complexes were characterized by circular dichroism analysis and X‐ray structure determination. This work constitutes a rare example of enantiomeric recognition resulting in spontaneous resolution upon crystallization.