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Orthogonally Photocontrolled Non‐Autonomous DNA Walker
Author(s) -
Škugor Marko,
Valero Julián,
Murayama Keiji,
Centola Mathias,
Asanuma Hiroyuki,
Famulok Michael
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201901272
Subject(s) - azobenzene , nanoscopic scale , molecular motor , nanotechnology , molecular machine , materials science , dna , computer science , chemistry , molecule , organic chemistry , biochemistry
There is considerable interest in developing progressively moving devices on the nanoscale, with the aim of using them as parts of programmable therapeutics, smart materials, and nanofactories. Present here is an entirely light‐induced DNA walker based on orthogonal photocontrol. Implementing two azobenzene derivatives, S‐DM‐Azo and DM‐Azo, enabled precise coordination of strand displacement reactions that powered a biped walker and guided it along a defined track in a non‐autonomous way. This unprecedented type of molecular walker design offers high precision control over the movement in back‐and‐forth directions as desired, and is regulated solely by the sequence of the irradiation wavelengths. This concept may open new avenues for advancing non‐autonomous progressive molecular motors, ultimately facilitating their application at the nanoscale.