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Chiral Resolution using Supramolecular‐Templated Mesostructured Materials
Author(s) -
Huang Yanan,
Vidal Xavier,
GarciaBennett Alfonso E.
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201900950
Subject(s) - enantiomer , mesoporous material , supramolecular chemistry , selectivity , circular dichroism , chemistry , mesoporous silica , mesoporous organosilica , chiral resolution , calcination , enantiomeric excess , adsorption , combinatorial chemistry , enantioselective synthesis , chemical engineering , molecule , materials science , organic chemistry , catalysis , stereochemistry , engineering
Chiral resolution using non‐functionalized mesoporous particles is demonstrated for a variety of enantiomeric pairs. This is achieved through the use of supramolecular templated silica materials prepared with guanosine monophosphate (NGM‐1) and folic acid (NFM‐1) which enable direct chiral transcription onto the surface of the mesopores after solvent extraction and post calcination of the template. The chiral selectivity and kinetics of the mesoporous materials are measured by circular dichroism (CD) spectroscopy on adsorbed molecules with different affinities for the pore surface. NGM‐1 and NFM‐1 have opposite enantiomeric selectivity for enantiomeric pairs. These results significantly increase the potential of mesoporous materials for chiral separation and enantiomeric catalysis.