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SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism
Author(s) -
Benson Sam,
Fernandez Antonio,
Barth Nicole D.,
de Moliner Fabio,
Horrocks Mathew H.,
Herrington C. Simon,
Abad Jose Luis,
Delgado Antonio,
Kelly Lisa,
Chang Ziyuan,
Feng Yi,
Nishiura Miyako,
Hori Yuichiro,
Kikuchi Kazuya,
Vendrell Marc
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201900465
Subject(s) - in vivo , in situ , live cell imaging , fluorescence , chemistry , biophysics , metabolism , preclinical imaging , cell , nanotechnology , biochemistry , biology , materials science , optics , physics , microbiology and biotechnology , organic chemistry
The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small‐sized multi‐colored fluorophores for real‐time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.