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Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores
Author(s) -
Megarity Clare F.,
Siritanaratkul Bhavin,
Heath Rachel S.,
Wan Lei,
Morello Giorgio,
FitzPatrick Sarah R.,
Booth Rosalind L.,
Sills Adam J.,
Robertson Alexander W.,
Warner Jamie H.,
Turner Nicholas J.,
Armstrong Fraser A.
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201814370
Subject(s) - nicotinamide adenine dinucleotide , nicotinamide , chemistry , nicotinamide adenine dinucleotide phosphate , electrode , cofactor , indium tin oxide , redox , reductase , enzyme , nad+ kinase , inorganic chemistry , biochemistry , oxidase test
In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP + are cycled rapidly between ferredoxin–NADP + reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme‐catalysed reactions.