Premium
Circular Polarized Light Activated Chiral Satellite Nanoprobes for the Imaging and Analysis of Multiple Metal Ions in Living Cells
Author(s) -
Gao Rui,
Xu Liguang,
Hao Changlong,
Xu Chuanlai,
Kuang Hua
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201814282
Subject(s) - metal ions in aqueous solution , deoxyribozyme , ion , chirality (physics) , metal , nanorod , materials science , detection limit , membrane , circular polarization , divalent , photon upconversion , chemistry , nanotechnology , luminescence , optoelectronics , optics , chromatography , physics , biochemistry , chiral symmetry breaking , organic chemistry , quantum mechanics , nambu–jona lasinio model , metallurgy , quark , microstrip
Here, we construct a handedness‐dependent circular polarized light (CPL)‐activated chiral satellite assemblies formed from DNAzymes and spiny platinum modified with gold nanorods and upconversion nanoparticles (UCNPs), enabling the simultaneous quantitative analysis of multiple divalent metal ions in living cells. The chiral nanoprobes, in coordination with their corresponding divalent metal ions under 980 nm left circular polarized (LCP) light illumination, served as an in situ confocal bioimaging platform for the quantitation of the given intracellular metal ions. The limit of detection (LOD) of the chiral probes in living cells is 1.1 nmol/10 6 cells, 1.02 nmol/10 6 cells and 0.45 nmol/10 6 cells for Zn 2+ , Mg 2+ , and Cu 2+ , respectively.