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Total Synthesis of Actinorhodin
Author(s) -
Ninomiya Mamiko,
Ando Yoshio,
Kudo Fumitaka,
Ohmori Ken,
Suzuki Keisuke
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201814172
Subject(s) - actinorhodin , regioselectivity , enantioselective synthesis , total synthesis , chemistry , monomer , oxidative phosphorylation , aryne , stereochemistry , combinatorial chemistry , organic chemistry , polyketide , catalysis , biosynthesis , biochemistry , polymer , enzyme
The enantioselective total synthesis of actinorhodin ( 1 ) is described. The synthesis features 1) dual benzyne reactions en route to the monomer, 2) the trans ‐selective installation of the side chain, and 3) a regioselective oxidative dimerization.
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