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Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach
Author(s) -
Nagaki Aiichiro,
Yamashita Hiroki,
Hirose Katsuyuki,
Tsuchihashi Yuta,
Yoshida Junichi
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201814088
Subject(s) - electrophile , chemistry , flash (photography) , bearing (navigation) , reactivity (psychology) , flow chemistry , functional group , microreactor , combinatorial chemistry , computational chemistry , organic chemistry , computer science , medicine , art , polymer , alternative medicine , pathology , artificial intelligence , visual arts , catalysis
Flash chemistry based on flow microreactor systems allowed alkyllithiums bearing electrophilic functional groups to be successfully generated and used for subsequent reactions. The series of reactions with high reactivity was achieved by extremely accurate control over residence time in a controlled and selective manner.