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Artificial K + Channels Formed by Pillararene‐Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential
Author(s) -
Xin Pengyang,
Kong Huiyuan,
Sun Yonghui,
Zhao Lingyu,
Fang Haodong,
Zhu Haofeng,
Jiang Tao,
Guo Jingjing,
Zhang Qian,
Dong Wenpei,
Chen ChangPo
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201813797
Subject(s) - selectivity , chemistry , kcsa potassium channel , lipid bilayer , membrane , molecule , ion channel , organic chemistry , biochemistry , receptor , catalysis
A class of artificial K + channels formed by pillararene‐cyclodextrin hybrid molecules have been designed and synthesized. These channels efficiently inserted into lipid bilayers and displayed high selectivity for K + over Na + in fluorescence and electrophysiological experiments. The cation transport selectivity of the artificial channels is tunable by varying the length of the linkers between pillararene and cyclodexrin. The shortest channel showed specific transmembrane transport preference for K + over all alkali metal ions (selective sequence: K + > Cs + > Rb + > Na + > Li + ), and is rarely observed for artificial K + channels. The high selectivity of this artificial channel for K + over Na + ensures specific transmembrane translocation of K + , and generated stable membrane potential across lipid bilayers.